• For full details of graphics available/in preparation, see Menu -> Planners
 Transplantation einer Schweine Niere infographic
Grafik zeigt die Stadien der Xenotransplantations Ttechnologie.
GN41918DE

GESUNDHEIT

Schweineniere wird in Menschen transplantiert

By Duncan Mil

October 21, 2021 - Zum ersten Mal ist die Niere eines gentechnisch veränderten Schweins in einen Menschen transplantiert worden, es kam zu keiner
hyperakuten Abstoßung durch das Immunsystem des Empfängers.

The surgery carried out on September 25 at NYU Langone Health in New York City involved a brain dead patient on a ventilator with signs of kidney dysfunction, whose family had permitted the three-day experiment for the sake of advancing science.

The researchers kept the pig kidney outside of the patient's body to observe and check it was doing its job during the operation. That is, filtering out waste products from the blood and producing urine.

The kidney made "the amount of urine that you would expect" from a transplanted human kidney, said transplant surgeon Dr Robert Montgomery, who led the study.

Humans and primates differ from other animals in that they lack an enzyme, alpha-gal (alpha 1,3 galactosyltransferase), that places a particular branched sugar group on the animal's cell surfaces.

The kidney was joined to blood vessels on the top of one of the patient's legs so that Montgomery's team could observe it and take biopsy samples.

Montgomery said that the recipient's abnormal creatinine level -- an indicator of poor kidney function -- returned to normal after the transplant.

The genetically modified pig, dubbed GalSafe, was developed by United Therapeutics Corp's Revivicor unit. The U.S. Food and Drug Administration approved it in December 2020 as a potential source of human therapeutics.

Sources
PUBLISHED: 21/10/2021; STORY: Graphic News; PICTURES: NYU Langone Health
Advertisement