Entwicklung von Impfstoffen infographic
Grafik zeigt die Schritte der Entwicklung eines Impfstoffs.
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GESUNDHEIT

Schritte zur Entwicklung von Impfstoffen

By Duncan Mil

March 17, 2020 - Die Suche nach einer Vakzine gegen das Coronavirus ist in vollem Gang, doch git es viele Hürden zu überwinden – Tierversuche, Tests an Menschen, Zulassungsbewilligung und Herstellung.

The Norway-based Coalition for Epidemic Preparedness Innovations (CEPI), made up of vaccine makers and health agencies -- is leading the bid to fast-track a vaccine.

Researchers in the U.S. at Massachusetts-based Moderna, a CEPI-sponsored start-up, began developing a “nucleic acid vaccine.” The vaccine contains the genetic recipe for human recipients to generate antigens -- in this case SARS-CoV-2 viral fusion proteins -- inside their body. These antigens then trigger the immune system to produce antibodies to block the virus.

Forty-five young, healthy volunteers began participating in a trial of Moderna’s vaccine at the Kaiser Permanente Washington Health Research Institute in Seattle on March 16.

A CEPI-sponsored team in Australia is also using the “spike protein” on the outside of the virus. The viral spike protein binds to a receptor on the human cell surface called ACE2 (Angiotensin-converting enzyme 2).

Before being injected into humans, a candidate vaccine goes through pre-clinical trials in which experiments on animals determine whether treatments are safe and effective.

In the next phase, a lengthy series of clinical trials evaluate the vaccine’s safety and ability to generate an immune system response.

The production of a vaccine for large-scale use could take 12–18 months and might not be possible during the current outbreak, explains Nicola Stonehouse, a professor in molecular virology at the University of Leeds. “What it might do is help control future outbreaks,” she says. “To make a vaccine conventionally -- to test it and get it on the market -- can take a decade.”

PUBLISHED: 18/03/2020; STORY: Graphic News
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