Malaria Behandlung mit einer Einzeldosis infographic
Grafik erklärt wie Krintafel den Lebenszyklus von P. vivax Malaria unterbricht.
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Malaria Einzeldosis Behandlung

July 23, 2018 - US Regulierungsbehörden haben die Zulassung für eine einfache Behandlung mit einer Einzeldosis gegen Neuauftreten des Plasmodium vivax Malaria erteilt. Eine Gabe von GlaxoSmithKlines Krintafel (Tafenoquin) verhindert das Wiederaufflammen von Malaria in drei von vier Patienten.

Antimalarial drugs can cure the initial malaria infection, but parasites can get into the liver, hide in a dormant form, and cause recurrences months or years later. A second drug is used to stop relapses.

Krintafel is an 8-aminoquinoline derivative, known as tafenoquine. Data analysed from a total of thirty-three studies -- involving more than 4,000 trial subjects exposed to the 300mg single-dose, and other doses of tafenoquine -- were effective against all stages of the P. vivax lifecycle, including hypnozoites -- the dormant version of the parasite that resides in the liver.

Scientists at the Walter Reed Army Institute of Research first synthesised tafenoquine in 1978. In 2008, GSK entered into a collaboration with the not-for-profit drug research partnership, MMV, to develop tafenoquine as an anti-relapse medicine for patients infected with P. vivax.

GlaxoSmithKline plans to apply for approval in Brazil, then other countries where P. vivax malaria is prevalent. It says it will sell the pills at low cost in developing countries.

PUBLISHED: 23/07/2018; STORY: Graphic News; PICTURES: CDC
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